What substance significantly alters dopamine processes and could lead to excited delirium?

Methamphetamine is known for its powerful stimulant effects, primarily because it significantly alters dopamine processes in the brain. This substance increases the release and action of dopamine, a neurotransmitter associated with pleasure, reward, and motor function. The sudden and intense stimulation of the dopaminergic system can lead to extreme agitation, paranoia, and heightened psychomotor activity, which are characteristic features of excited delirium.

Excited delirium is a state often associated with acute psychiatric conditions or substance abuse, where an individual exhibits severe agitation, disorientation, and potential violent behavior. Methamphetamine's impact on dopamine is particularly potent compared to other substances like caffeine, alcohol, or nicotine, making it a specific risk factor for this dangerous condition. This distinctive profile of methamphetamine as a powerful central nervous system stimulant that adversely affects dopamine levels helps clarify why it is linked to increased instances of excited delirium.